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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Nanoparticle-plasma Membrane Interactions: Thermodynamics, Toxicity and Cellular Response

Author(s): Ana G. Rodríguez-Hernández , Rafael Vazquez-Duhalt and Alejandro Huerta-Saquero *

Volume 27, Issue 20, 2020

Page: [3330 - 3345] Pages: 16

DOI: 10.2174/0929867325666181112090648

Price: $65

Abstract

Nanomaterials have become part of our daily lives, particularly nanoparticles contained in food, water, cosmetics, additives and textiles. Nanoparticles interact with organisms at the cellular level. The cell membrane is the first protective barrier against the potential toxic effect of nanoparticles. This first contact, including the interaction between the cell membranes -and associated proteins- and the nanoparticles is critically reviewed here. Nanoparticles, depending on their toxicity, can cause cellular physiology alterations, such as a disruption in cell signaling or changes in gene expression and they can trigger immune responses and even apoptosis. Additionally, the fundamental thermodynamics behind the nanoparticle-membrane and nanoparticle-proteins-membrane interactions are discussed. The analysis is intended to increase our insight into the mechanisms involved in these interactions. Finally, consequences are reviewed and discussed.

Keywords: Nanoparticles-plasma membrane interactions, Nanoparticles-protein interactions, Thermodynamics, Toxicity, Cellular Response, cell membrane.

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