[1,2,3]-Benzotriazines represent an interesting category of heterocyclic compounds.
Various synthetic methods, key reactions and biological aspects have been highlighted.
In particular, some analogues have shown antitumor activity. [1,2,3]-
Benzotriazin-4-one derivatives are applied extensively as herbicides, insecticides and
nematicides. Incorporation of these compounds into the human food chain is a cause of
concern, since their toxicity to man is well documented. This review is an attempt to discuss
synthesis, chemical reactions, applications and pharmacological aspects of [1,2,3]-
benzotriazine analogues from 1957 till date.
Keywords: [1, 2, 3]- Benzotriazines, [1, 2, 3]- BenzotriazineN-oxide, [1, 2, 3]- Benzotriazin-4(3H)-one, 4- Hydroxy- [1, 2, 3]-benzotriazines,
coupling agent, HOOBt.
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