The emergence of multidrug-resistant (MDR) pathogens and cancers alarms the
world for the urgent exploration of new therapeutic drugs to treat the superbugs and cancer
patients. Since the ancient time, natural products and/or their derivatives have become
continuous sources of leading commercialized pharmacological compounds that are used
as antibiotics and antitumor agents. An unexplored source of natural products, lichen, currently
has evolved into a propitious source of diverse secondary metabolites with various
bio-activities including anticancer and antimicrobial, offering the abundant potentiality for
future drugs. Herein, we summarized the progress in the discovery of structurally diverse
anticancer compounds (C1-C85) with their plausible mode of action and antimicrobial
compounds (M1-M112) from lichen and lichen-derived fungi together with their biodiversity.
This review covers natural products discussed in literature from January 1985 to December 2017.
Keywords: Lichen, anticancer and antimicrobial, biodiversity, diverse metabolites, secondary metabolites, lichenized fungi.
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