Aryl Hydrocarbon Receptor: Its Regulation and Roles in Transformation and Tumorigenesis

Author(s): Xun Che, Wei Dai*

Journal Name: Current Drug Targets

Volume 20 , Issue 6 , 2019

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Graphical Abstract:


Abstract:

AhR is an environmental response gene that mediates cellular responses to a variety of xenobiotic compounds that frequently function as AhR ligands. Many AhR ligands are classified as carcinogens or pro-carcinogens. Thus, AhR itself acts as a major mediator of the carcinogenic effect of many xenobiotics in vivo. In this concise review, mechanisms by which AhR trans-activates downstream target gene expression, modulates immune responses, and mediates malignant transformation and tumor development are discussed. Moreover, activation of AhR by post-translational modifications and crosstalk with other transcription factors or signaling pathways are also summarized.

Keywords: Aryl hydrocarbon receptor, xenobiotics, carcinogenesis, transcription factor, post-translation modification, review.

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Article Details

VOLUME: 20
ISSUE: 6
Year: 2019
Page: [625 - 634]
Pages: 10
DOI: 10.2174/1389450120666181109092225
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