Green Procedure for One-Pot Synthesis of Azelaic Acid Derivatives Using Metal Catalysis

Author(s): Amelita Grazia Laurenza, Michele Casiello, Marco Anzivino, Daniela Caputo, Lucia Catucci, Maria Michela Dell'Anna, Caterina Fusco, Vito Rizzi, Vincenzo Pantone, Lucia D’Accolti*, Angelo Nacci

Journal Name: Recent Innovations in Chemical Engineering
Formerly Recent Patents on Chemical Engineering

Volume 11 , Issue 3 , 2018

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Graphical Abstract:


Background & Objective: A green one-pot synthesis of oleic acid (1) derivatives is promoted by Rare Earth Metal (REM) triflates and commercial Molybdenum dioxo dichloride (MoCl2O2) in the presence hydrogen peroxide as a green oxidant.

Results: The protocol permits to govern the oxidation selectivity by simply choosing the proper combination of Mo and Sc catalysts.

Conclusion: Methyl oleate epoxide 2a and azelaic acid 6 thus obtained are valuable industrial intermediates for synthesizing bio-compostable plastics, plasticizers of PVC, lubricating oils, cosmetics and pharmaceuticals (bactericides, anti-inflammatories, etc.).

Keywords: Removable resource, rare earth, molybdenum complex, sustainability, azelaic acid, green chemistry.

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Article Details

Year: 2018
Published on: 11 January, 2019
Page: [185 - 191]
Pages: 7
DOI: 10.2174/2405520411666181102162637

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