Background: Synthetic compounds with pharmaceutical applications in brain disorders
are daily designed and synthesized, with well first effects but also seldom severe side
effects. This imposes the search for alternative therapies based on the pharmaceutical potentials
of natural compounds. The natural compounds isolated from various plants and arthropods
venom are well known for their antimicrobial (antibacterial, antiviral) and antiinflammatory
activities, but more studies are needed for a better understanding of their structural
and pharmacological features with new therapeutic applications.
Objectives: Here we present some structural and pharmaceutical features of natural compounds
isolated from plants and arthropods venom relevant for their efficiency and potency in
brain disorders. We present the polytherapeutic effects of natural compounds belonging to
terpenes (limonene), monoterpenoids (1,8-cineole) and stilbenes (resveratrol), as well as natural
peptides (apamin, mastoparan and melittin).
Methods: Various experimental and in silico methods are presented with special attention on
bioinformatics (natural compounds database, artificial neural network) and cheminformatics
(QSAR, drug design, computational mutagenesis, molecular docking).
Results: In the present paper we reviewed: (i) recent studies regarding the pharmacological
potential of natural compounds in the brain; (ii) the most useful databases containing molecular
and functional features of natural compounds; and (iii) the most important molecular descriptors
of natural compounds in comparison with a few synthetic compounds.
Conclusion: Our paper indicates that natural compounds are a real alternative for nervous
system therapy and represents a helpful tool for the future papers focused on the study of the