Chemistry of α-(arylhydrazono)-β-ketoaldehydes: Preparation and Chemical Reactivities

Author(s): Hatem M. Gaber, Sobhi M. Gomha*, Thoraya A. Farghaly*, Zeinab A. Muhammad, Mark C. Bagley

Journal Name: Current Organic Chemistry

Volume 22 , Issue 27 , 2018

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Graphical Abstract:


The following review provides up to date information about the recent progress in synthetic approaches and chemical reactivities to α-(arylhydrazono)-β-ketoaldehydes, mainly using N,N-dimethyl-β-ketoenamines as an efficient starting material. These α - (arylhydrazono)-β-ketoaldehydes have assured to be of biological interest and furnish an inlet to a new class of biologically active heterocyclic compounds for biomedical implementations. The data published until the end of 2017 have been covered.

Keywords: 2-arylhydrazonals, N, N-dimethylenamino-ketones, coupling reactions, α-(arylhydrazono)-β-ketoaldehydes, active methylene, nitrogen-nucleophiles.

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Article Details

Year: 2018
Published on: 14 January, 2019
Page: [2599 - 2633]
Pages: 35
DOI: 10.2174/1385272822666181025145512
Price: $58

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