The benzimidazole moiety is a privileged heterocyclic nucleus which has been
used broadly in medicinal chemistry. Benzimidazole derivatives are useful building blocks
for the development of important compounds of biological and therapeutic interest. The
developments of facile synthetic routes to achieve access to these molecules are of prime
interest, therefore synthetic organic chemists focused to invent an efficient method for the
synthesis of benzimidazole derivatives.
In recent years, several reports have been evident forthe synthesis of these heterocyclic
compounds in the presence of various conditions; like solvent free, reactant immobilized
on solid support, microwave irradiation condition, using various solvents and using different
catalysts. Therefore in the present review, we tried to represent a systematic survey on
various synthetic strategies leading to the synthesis of compounds bearing benzimidazole moiety by the direct
condensation reaction carried out between o-phenylenediamine and aromatic aldehydes using differentcatalytic
reagents during last 10 years. This review is a brief account of some frequently used methods to synthesize
benzimidazole derivatives using different type of catalysts in various conditions.
Keywords: Synthesis, benzimidazoles, aldehydes, o-phenylenediamine, nano-catalysts, heterogeneous, microwave irradiation.
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