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Current Pharmaceutical Analysis

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ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

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Research Article

Rapid Electrochemical Ultra-Sensitive Evaluation and Determination of Daptomycin Based on Continuous Cyclic Voltammetry

Author(s): Navid Rabiee, Moein Safarkhani and Mohammad Rabiee*

Volume 16, Issue 2, 2020

Page: [181 - 185] Pages: 5

DOI: 10.2174/1573412914666181017134015

Price: $65

Abstract

Background: In this work, a novel and extra sensitive blood sample determination method for on-line monitoring of Daptomycin is represented.

Materials and Methods: This technique is in accordance with the electro-membrane extraction (EME) and stripping fast Fourier transform continuous cyclic voltammetry (SFFTCCV) coupling. Briefly, the potential waveform had become constantly utilized over a Gold Electrode and the electrode impulse was acquired by taking away the base current and developing the current in the particular potential area of oxidation of sample.

Results: This method was performed by utilizing a DC potential and migration of Daptomycin from the analyte fluid to the layer of 4-methyl-2-pentanol as well as following migration to the acceptor fluid.

Conclusion: A low and valuable detection limit of 3.5 ng ml-1 and quantification limit of 10.2 ng ml-1 are considered as a part of the sensible results of this experiment. Furthermore, efficient linearity in the range of 10.0-600 ng ml-1 was observed.

Keywords: Daptomycin, electrochemical, rapid determination, continuous cyclic voltammetry, ultra-sensitive, resistance mechanisms.

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