Correlation of Serum Magnesium with Insulin Resistance in North Indian Adult Population

Author(s): Geeta Shamnani, Shekhawat S. Bhartiy*, Rekha Jiwane, Vani Gupta, Narsingh Verma, Dileep Verma

Journal Name: Current Diabetes Reviews

Volume 16 , Issue 3 , 2020

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Background: Globalization has lead to such lifestyle changes which have produced increase in incidence and prevalence of Type 2 Diabetes Mellitus (T2DM). Magnesium is found to have some role in glucose metabolism. The aim of this study was to investigate the relationship between serum magnesium levels with insulin resistance in apparently healthy adults.

Objective: The objective of our study was to evaluate correlation of serum magnesium with fasting blood sugar, insulin level and Homeostasis model assessment-insulin resistance (HOMA-IR) index (indicator of insulin resistance) on the basis of the hypothesis that subjects with hypomagnesaemia are more prone to develop hyperglycemia and insulin resistance.

Materials and Methods: The study was a cross-sectional study which was population based. Total 130 apparently healthy adults of age between 25-65 years, were recruited with prior ethical approval and written informed consent.

Results: Serum magnesium was found to be negatively correlated with fasting blood sugar (FBS), insulin level and HOMA-IR. Co-relation of magnesium with FBS (r = -0.55, p<0.0001), insulin (r = -0.45, p< 0.0001) and HOMA-IR (r = -0.52, p<0.0001) was significant.

Conclusion: As per findings it was concluded that serum magnesium was found to have significant negative correlation with fasting blood sugar (FBS), insulin and HOMA-IR, thus hypomagnesaemia can be suggested to be one of the important predictor of type 2 diabetes mellitus.

Keywords: Serum magnesium, fasting blood sugar, insulin, HOMA-IR and hypomagnesaemia, type 2 diabetes mellitus, North Indian adult population.

Zimmet PZ, Magliano DJ, Herman WH, Shaw JE. Diabetes: a 21st century challenge. Lancet Diabetes Endocrinol 2014; 2(1): 56-64.
[] [PMID: 24622669]
Gill H, Mugo M, Whaley-Connell A, Stump C, Sowers JR. The key role of insulin resistance in the cardiometabolic syndrome. Am J Med Sci 2005; 330(6): 290-4.
[] [PMID: 16355013]
Petersen KF, Shulman GI. Etiology of insulin resistance. Am J Med 2006; 119(5)(Suppl. 1): S10-6.
[] [PMID: 16563942]
Mohan LK. Escott- Stump S Nutrition Basis Krause food and nutrition therapy. 12th ed. Philadelphia Imprint saunders. 2012; p. 110-1.
Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 2000; 294(1-2): 1-26.
[] [PMID: 10727669]
Kratz A, Pesce MA, Basner RC, Einstein AJ. Laboratory Values of Clinical Importance.Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameso JL, Loscalzo J(Eds) Harrison’s principal of internal medicine 19th ed. McGrawHill Education’s Professional Publish- ing Division 2015; p. 2761.
Insel P, Turner RE, Ross D. Water and Minerals: The Ocean within. In: Discovering Nutrition. 3rd ed. Jones and Bartlett Learning 2009; pp. 420-1.
Li FY, Chaigne-Delalande B, Kanellopoulou C, et al. Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature 2011; 475(7357): 471-6.
[] [PMID: 21796205]
Ryan MF. The role of magnesium in clinical biochemistry: an overview. Ann Clin Biochem 1991; 28(Pt 1): 19-26.
[] [PMID: 2024929]
Fawcett WJ, Haxby EJ, Male DA. Magnesium: physiology and pharmacology. Br J Anaesth 1999; 83(2): 302-20.
[] [PMID: 10618948]
Quamme GA, Rabkin SW. Cytosolic free magnesium in cardiac myocytes: identification of a Mg2+ influx pathway. Biochem Biophys Res Commun 1990; 167(3): 1406-12.
[] [PMID: 2322282]
Yu AS. Evolving concepts in epithelial magnesium transport. Curr Opin Nephrol Hypertens 2001; 10(5): 649-53.
[] [PMID: 11496060]
Young DS. Effects of preanalytical variables on clinical laboratory tests. 2nd ed. Washington: AACC 1997.
Bardicef M, Bardicef O, Sorokin Y, et al. Extracellular and intracellular magnesium depletion in pregnancy and gestational diabetes. Am J Obstet Gynecol 1995; 172(3): 1009-13.
[] [PMID: 7892840]
González-Revaldería J, García-Bermejo S, Menchén-Herreros A, Fernandez-Rodriguez E. Biological variation of Zn, Cu, and Mg in serum of healthy subjects. Clin Chem 1990; 36(12): 2140-1.
[PMID: 2253367]
Guerrera MP, Volpe SL, Mao JJ. Therapeutic uses of magnesium. Am Fam Physician 2009; 80(2): 157-62.
[PMID: 19621856]
Elin RJ. Assessment of magnesium status for diagnosis and therapy. Magnes Res 2010; 23(4): S194-8.
[PMID: 20736141]
Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: are the health consequences underestimated? Nutr Rev 2012; 70(3): 153-64.
[] [PMID: 22364157]
Nadler JL, Rude RK. Disorders of magnesium metabolism. Endocrinol Metab Clin North Am 1995; 24(3): 623-41.
[] [PMID: 8575413]
Mooren FC, Krüger K, Völker K, Golf SW, Wadepuhl M, Kraus A. Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial. Diabetes Obes Metab 2011; 13(3): 281-4.
[] [PMID: 21205110]
Romero FG, Morán MR. Magnesium improves the beta cell func- tion to compensate variation of insulin sensitivity: double blind, randomized clinical trial. Eur J Clin 2011; 41: 405-10.
Solati M, Ouspid E, Hosseini S, Soltani N, Keshavarz M, Dehghani M. Oral magnesium supplementation in type II diabetic patients. Med J Islam Repub Iran 2014; 28: 67.
[PMID: 25405132]
Wang JL, Shaw NS, Yeh HY, Kao MD. Magnesium status and association with diabetes in the Taiwanese elderly. Asia Pac J Clin Nutr 2005; 14(3): 263-9.
[PMID: 16169838]
Swaminathan R. Disorders of metabolism 2Textbook of Ad- verse Drug Reactions. 5th ed. London: Chapman & Hall Medical 1998; pp. 442-540.
Markmann M, Rothman R, Reichman B, et al. Persistent hypomagnesemia following cisplatin chemotherapy in patients with ovarian cancer. J Cancer Res Clin Oncol 1991; 117(2): 89-90.
[] [PMID: 2007614]
Koch Nogueira PC, Hadj-Aïssa A, Schell M, Dubourg L, Brunat-Mentigny M, Cochat P. Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma. Pediatr Nephrol 1998; 12(7): 572-5.
[] [PMID: 9761357]
Swaminathan R. Hypo - hypermagnesaemia In: Oxford Textbook of Nephrology. Eds: Davison AM, Cameron JS, Gunfield J-P, Kerr DNS, Ritz E, Winearls. 2nd ed.. Oxford : Oxford University Press 1998; pp. 271-310.
Elliott C, Newman N, Madan A. Gentamicin effects on urinary electrolyte excretion in healthy subjects. Clin Pharmacol Ther 2000; 67(1): 16-21.
[] [PMID: 10668849]
Vamvakas S, Teschner M, Bahner U, Heidland A. Alcohol abuse: potential role in electrolyte disturbances and kidney diseases. Clin Nephrol 1998; 49(4): 205-13.
[PMID: 9582549]
Gullestad L, Dolva LO, Waage A, Falch D, Fagerthun H, Kjekshus J. Magnesium deficiency diagnosed by an intravenous loading test. Scand J Clin Lab Invest 1992; 52(4): 245-53.
[] [PMID: 1439510]
Rivlin RS. Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development (a review). J Am Coll Nutr 1994; 13(5): 416-23.
[] [PMID: 7836619]
Dai LJ, Ritchie G, Kerstan D, Kang HS, Cole DE, Quamme GA. Magnesium transport in the renal distal convoluted tubule. Physiol Rev 2001; 81(1): 51-84.
[] [PMID: 11152754]
Vetter T, Lohse MJ. Magnesium and the parathyroid. Curr Opin Nephrol Hypertens 2002; 11(4): 403-10.
[] [PMID: 12105390]
Günther T. The biochemical function of Mg2+ in insulin secretion, insulin signal transduction and insulin resistance. Magnes Res 2010; 23(1): 5-18.
[] [PMID: 20228013]
Sales CH, Pedrosa Lde F. Magnesium and diabetes mellitus: their relation. Clin Nutr 2006; 25(4): 554-62.
[] [PMID: 16690176]
Rodriguez-Morán M, Guerrero-Romero F. Elevated concentrations of TNF-alpha are related to low serum magnesium levels in obese subjects. Magnes Res 2004; 17(3): 189-96.
[PMID: 15724867]
Barbagallo M, Dominguez LJ, Galioto A, et al. Role of magnesium in insulin action, diabetes and cardio-metabolic syndrome X. Mol Aspects Med 2003; 24(1-3): 39-52.
[] [PMID: 12537988]
Shechter M, Sharir M, Labrador MJ, Forrester J, Silver B, Bairey Merz CN. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation 2000; 102(19): 2353-8.
[] [PMID: 11067788]
Schram MT, Stehouwer CD. Endothelial dysfunction, cellular adhesion molecules and the metabolic syndrome. Horm Metab Res 2005; 37(Suppl. 1): 49-55.
[] [PMID: 15918111]
Song Y, Li TY, van Dam RM, Manson JE, Hu FB. Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women. Am J Clin Nutr 2007; 85(4): 1068-74.
[] [PMID: 17413107]
Ankush RD, Suryakar AN, Ankush NR. Hypomagnesaemia in type-2 diabetes mellitus patients: A study on the status of oxidative and nitrosative stress. Indian J Clin Biochem 2009; 24(2): 184-9.
[] [PMID: 23105830]
Voma C, Romani AMP. Role of magnesium in regulation of glucose homeostasis Szablewski L Intech: Glucose homeostasis 2014; 101-4.
Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes Care 2010; 33(12): 2604-10.
[] [PMID: 20807870]
Longstreet DA, Heath DL, Panaretto KS, Vink R. Correlations suggest low magnesium may lead to higher rates of type 2 diabetes in Indigenous Australians. Rural Remote Health 2007; 7(4): 843.
[PMID: 17937505]
Randell EW, Sun G. Positive correlation between total serum mag- nesium and serum lipid levels in the general population is clear: Ionized magnesium remains to be examined. Atherosclerosis 2007; 192(1): 231-2.
Nanri A, Mizoue T, Noda M, et al. Magnesium intake and type II diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study. Eur J Clin Nutr 2010; 64(10): 1244-7.
[] [PMID: 20664621]
Simmons D, Joshi S, Shaw J. Hypomagnesaemia is associated with diabetes: Not pre-diabetes, obesity or the metabolic syndrome. Diabetes Res Clin Pract 2010; 87(2): 261-6.
[] [PMID: 20004036]
Lima de Souza E Silva MdeL, Cruz T, Rodrigues LE, et al.. Magnesium replacement does not improve insulin resistance in patients with metabolic syndrome: a 12-week randomized double-blind study. J Clin Med Res 2014; 6(6): 456-62.
[] [PMID: 25247020]
Bo S, Durazzo M, Guidi S, et al. Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a population-based cohort. Am J Clin Nutr 2006; 84(5): 1062-9.
[] [PMID: 17093158]
Derakhshan R, Balaee P, Darakhshan S, Masoodpoor N, Banihosseini SS. Lipid profile, thyroid function, and serum magnesium level in type I diabetic children. Minerva Pediatr 2011; 63(1): 27-33.
[PMID: 21311427]

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Year: 2020
Page: [254 - 261]
Pages: 8
DOI: 10.2174/1573399814666181016164432
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