Sjögren’s syndrome (SS) is an immune system oral disorder that is characterized generally by dry
mouth and eyes. In this review, SS classification, presentation and pathogenesis are briefly discussed. Moreover,
the epidemiology of SS regarding sex, age and association with other complications are also presented. This review
also addresses the interactions between endocrine axes and SS, and the important findings up to regarding
hormone treatment of this syndrome. The main hormones discussed in this review includes Adrenocorticotropic
hormone (ACTH), Follicle-stimulating hormone (FSH), Luteinizing hormone (LH), Thyroid-stimulating hormone
(TSH), and prolactin.