Carbocyclic Analogues of Distamycin and Netropsin

Author(s): Karolina Arciszewska, Anna Pućkowska, Agnieszka Wróbel, Danuta Drozdowska*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 19 , Issue 2 , 2019

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Graphical Abstract:


The DNA as the depository of genetic information is a natural target for chemotherapy. A lot of anticancer and antimicrobial agents derive their biological activity from their selective interaction with DNA in the minor groove and from their ability to interfere with biological processes such as enzyme catalysis, replication and transcription. The discovery of the details of minor groove binding drugs, such as netropsin and distamycin A, oligoamides built of 4-amino-1-methylpyrrole-2-carboxylic acid residues, allowed to develop various DNA sequence-reading molecules, named lexitropsins, capable of interacting with DNA precisely, strongly and with a high specificity, and at the same time exhibiting significant cytotoxic potential. Among such compounds, lexitropsins built of carbocyclic sixmembered aromatic rings occupy a quite prominent place in drug research. This work is an attempt to present current findings in the study of carbocyclic lexitropins, their structures, syntheses and biological investigations such as DNA-binding and antiproliferative activity.

Keywords: Distamycin, netropsin, minor groove binder, lexitropsin, carbocyclic analogue, anticancer drug, drug design.

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Year: 2019
Published on: 06 December, 2018
Page: [98 - 113]
Pages: 16
DOI: 10.2174/1389557518666181009143203
Price: $65

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