Title:Metabolomics-based Approach to Pharmacotherapy Personalization: Advantages and Limitations
VOLUME: 16 ISSUE: 3
Author(s):Dmitry L. Maslov*, Elena E. Balashova, Oxana P. Trifonova and Petr G. Lokhov
Affiliation:Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow, Institute of Biomedical Chemistry, 10 Building 8, Pogodinskaya Street, 119121, Moscow
Keywords:Metabolomics, pharmacometabolomics, pharmacogenomics, personalized medicine, mass spectrometry,
metabolomics-based approach.
Abstract:Background: A patient-focused approach to treatment, where individual characteristics
provide the selection of optimal medication strategy for a particular patient, is
the trend of current clinical therapy. An application of advanced “omics” technologies,
which enable to detect the inter-individual variability in genomic, transcriptomic, proteomic,
and metabolomic levels is a perspective way to achieve such personalization.
Objective: In this review, the advantages of metabolomics-based approach as one of the
most promising and perspective for individualization of pharmacotherapy are demonstrated.
This approach provides a prediction of the inter-individual variability in drug response
and allows monitoring effectiveness of drug treatment, correcting it in account of
individual parameters of patients.
Method: Comparative analysis of metabolomics-based approach and the current methods
of drug treatment personalization are carried out.
Results: Advantages and limitations of the metabolomics-based approach were identified
and discussed.
Conclusion: The perspective ways for solution of limitations of the metabolomics-based
approach are considered.
