Malic Acid as Bioorganocatalyst: Sustainable, One-pot and Multicomponent Synthesis of Benzopyrimido[4,5-b]quinoline in Biodegradable Glycerol

Author(s): Akhilesh Kumar, Pragati Rai, Vijay B. Yadav, Hozeyfa Sagir, I. R. Siddiqui*

Journal Name: Current Organocatalysis

Volume 5 , Issue 3 , 2018

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Background: Herein we disclosed a clean and sustainable, one pot, multicomponent protocol for the synthesis of Benzopyrimido[4,5-b]quinoline in glycerol in the presence of malic acid.

Methods: The reported strategy eliminates the use of hazardous transition metal catalysts, acid, base and volatile organic solvents, which negatively affect the environment. In addition present methodology has advantages of mild reaction conditions, wide substrate scope, operational simplicity, easy workup, cost effectiveness and high yields of desired products.

Conclusion: We have presented an efficient malic acid promoted, environmentally benign synthetic route to highly functionalized benzo[f]pyrimido[4,5-b]quinoline derivatives.

Keywords: 5-b]quinolone, benzopyrimido, cost effectiveness, malic acid, multicomponent, yields.

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2018
Published on: 14 February, 2019
Page: [239 - 245]
Pages: 7
DOI: 10.2174/2213337205666181008103213

Article Metrics

PDF: 32