Surface Enhanced Raman Spectroscopy (SERS) has a long history as an
ultrasensitive platform for the detection of biological species from small aromatic molecules
to complex biological systems as circulating tumor cells. Thanks to unique properties of graphene,
the range of SERS applications has largely expanded. Graphene is efficient fluorescence
quencher improving quality of Raman spectra. It contributes also to the SERS enhancement
factor through the chemical mechanism. In turn, the chemical flexibility of Reduced
Graphene Oxide (RGO) enables tunable adsorption of molecules or cells on SERS active
surfaces. Graphene oxide composites with SERS active nanoparticles have been also applied
for Raman imaging of cells. This review presents a survey of SERS assays employing
graphene or RGO emphasizing the improvement of SERS enhancement brought by graphene
or RGO. The structure and physical properties of graphene and RGO will be discussed too.
Keywords: SERS platform, biosensors, theranostics, diagnosis, graphene, cancer cells, reduced graphene oxide.
Ashworth, T.R. A case of cancer in which cells similar to those in the tumors were seen in the blood after dead. Aust. Med. J., 1869, 14, 146-147.
Rights & PermissionsPrintExport