In vitro Characterization of Microspheres Containing Chemically Cross- Linked Gummy Exudates of Cochlospermum religiosum

Author(s): Vipin Kumar Sharma*, Bhaskar Mazumder, Vinod Nautiyal, Prince Prashant Sharma, Yusra Ahmed

Journal Name: The Natural Products Journal

Volume 9 , Issue 3 , 2019

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Graphical Abstract:


Background: The polymeric hydrocolloids of natural origin such as gums and mucilages have their own significance in food and pharmaceutical industries due to safety, cost, biodegradability, biocompatibility, etc.

Objective: This study includes the assessment of feasibility of gummy exudates of Cochlospermum religiosum for development of microspheres through emulsification technique.

Methods: The effects of exudates concentration, glutaraldehyde amount and process temperature were analyzed on particle-size and swelling dynamics of developed microspheres. The formulations were also characterized by thermal decomposition and powder X-ray diffraction technique to assess the effect of crosslinking.

Results: The photomicrographs of preparations revealed the formation of microspheres with smooth, spherical and free-flowing nature. The swelling dynamics followed Fick’s diffusion mechanism for swelling media. Fourier transform infrared spectroscopy showed the formation of ether-linkage after crosslinking of exudates by glutaraldehyde. The thermogravimetric curves disclosed the formation of strong bonds during crosslinking.

Conclusion: The ease of gummy exudates of Cochlospermum religiosum for microspheres formation ascribed the potential of these formulations to incorporate therapeutic agent(s) to be applied as novel drug-carriers.

Keywords: Swelling dynamics, thermogravimetry, powder X-ray diffractometry, crosslinking, gummy exudates, thermal decomposition.

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Article Details

Year: 2019
Page: [217 - 228]
Pages: 12
DOI: 10.2174/2210315508666181004144520
Price: $25

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