Title:Pharmacological Effects of Carvacrol in In vitro Studies: A Review
VOLUME: 24 ISSUE: 29
Author(s):Erika Ramos Silva, Fernanda Oliveira de Carvalho, Luciana Garcez Barretto Teixeira, Nayara Gomes Lima Santos, Fernanda Araújo Felipe, Hericalizandra Santa Rosa Santana, Saranavan Shanmugam, Lucindo José Quintans Júnior, Adriano Antunes de Souza Araújo and Paula Santos Nunes*
Affiliation:Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE, Health Sciences Post-Graduate Program, Federal University of Sergipe, Claudio Batista St s/n, CEP 49060-100, Aracaju, SE
Keywords:Carvacrol, monoterpene, natural product, pharmacology, in vitro models, antimicrobial.
Abstract:Carvacrol has a high therapeutic potential, with in vitro studies showing promising results in different
cellular models using a variety of methodological designs. Therefore, the objective of this study was to conduct a
systematic review to analyze the pharmacological effects of carvacrol in in vitro studies. A comprehensive search
of the literature was made using four databases: Science Direct, Scopus, MEDLINE-PubMed, and Web of Science
using different combinations of the following keywords: carvacrol, drug therapy, therapeutic uses, in vitro
study. The search of the databases was for studies conducted in the period up to and including September 2016. A
total of 3,269 studies were initially identified, with only 31 meeting the inclusion criteria. The included studies
contained a variety of in vitro models able to determine the properties of Carvacrol. The following properties of
Carvacrol were identified: antimicrobial (7 studies), bactericidal (4), bactericidal and antifungal (1), antiinflammatory
(4), anticancer (4), mutagenic (4), antioxidant (3), antifungal (3), antidepressant (1), as a modulator
of nerve impulses (1) and an immunological modulator (1). The In vitro studies with Carvacrol included in this
review showed a diversity of models and confirmed the therapeutic potential of this product in relation to several
diseases.
