In this review, Ebolavirus Disease (EVD) outbreaks have been comprehensively reviewed
from their beginning until now. It chronologically discusses how each outbreak was tackled,
national and international actions taken, diagnostic methods applied, the infection control procedures
put in place, and the lessons learnt from each epidemic for the control of subsequent epidemics.
Data for this review were obtained from literature published between 1967 and 2016 in
key medical databases, the official websites of various governmental organisations, international
public health agencies, and regulatory bodies. Despite major developments in the field of EVD,
there has been little progress in its specific therapy or prevention. Historically, individuals who
recovered from EVD acted as a source of fresh frozen plasma (containing IgG) that has been used
to treat other acutely ill patients, however this therapeutic modality has limitations due to the risk
of transmission of blood-borne infections. With the use of advanced and efficient purification
methods the incidence of unwanted side effects following immune serum therapy has currently
been greatly reduced. Creation of a safe plasma pool that covers immunoglobulins against all
strains of EVD is now a research priority. Recommendations on how future EVD outbreaks can be
better managed have been discussed.