Myxedema Heart Disease: A Rare Disease Entity: Case Report and Brief Review of the Literature

Author(s): Muhammad Ali Chaudhry*, Luanda Grazette, Michael W. Fong

Journal Name: Current Hypertension Reviews

Volume 15 , Issue 1 , 2019

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Graphical Abstract:


Background: Myxedema heart disease is an extremely rare disease entity and should be suspected in patients with unexplained heart failure refractory to conventional treatment. Myxedema coma with co- existent heart disease is not well known and very few cases have been reported.

Conclusion: Here, we present an interesting case of myxedema coma with severe valvular cardiomyopathy followed by a concise review of the literature with special emphasis on epidemiology, pathophysiology, diagnosis and therapeutic modalities.

Keywords: Myxedema heart disease, brief review, heart failure, cardiomyopathy, epidemiology, pathophysiology.

Zondek II. Das Myxodeinherz, Miinchen med. Wchnschr 1918; 65: 1180-2.
Fahr G. Myxedema heart. J Am Med Assoc 1925; 84: 345-9.
Nicoloff JT, LoPresti JS. Myxedema coma. A form of decompensated hypothyroidism. Endocrinol Metab Clin North Am 1993; 22: 279-90.
Higgins WH. The heart in myxedema: Correlation of physical and postmortem findings. Am J Med Soc 1936; 191: 80-8.
Nicoloff JT, LoPresti JS. Myxedema coma. A form of decompensated hypothyroidism. Endocrinol Metab Clin North Am 1993; 22(2): 279-90.
Ballester JM, Harchelroad FP. Hypothermia: An easy-to-miss, dangerous disorder in winter weather. Geriatrics 1999; 54: 51-2.
Olsen CG. Myxedema coma in the elderly. J Am Board Fam Pract 1995; 8: 376-83. [Published errata appeared in J Am Board Fam Pract 1995; 8: 502 and 1996; 9: 63].
Smallridge RC. Metabolic and anatomic thyroid emergencies: A review. Crit Care Med 1992; 20: 276-91.
Alexander JS. Pericardial effusion of ‘Gold Paint’ appearance due to presence of cholesterin. BMJ 1919; 2(3067): 463.
Kern RA, Soloff LA, Snope WJ, Bello CT. Pericardialeffusion: A constant, early and major factor in the cardiac syndrome of hypothyroidism (myxedema heart). Am J Med Sci 1949; 217: 609.
Kerber RE, Sherman B. Echocardiographic evaluation of pericardial effusion in myxedema. Incidence and biochemical and clinical correlations. Circulation 1975; 52(5): 823-7.
Kirsch M, Rimpau C, Nickel CH, Baier P. Intracerebral bleeding and massive pericardial effusion as presenting symptoms of myxedema crisis. Case Rep Emerg Med 2017; 2017: 8512147.
Manfredi E, van Zaane B, Gerdes VE, Brandjes DP, Squizzato A. Hypothyroidism and acquired von Willebrand’s syndrome: A systematic review. Haemophilia 2008; 14(3): 423-33.
Mehta S. Cardiac tamponade; A rare presentation of childhood hypothyroidism. Iran J Pediatr 2014; 24(5): 663-4.
Majid-Moosa A, Schussler JM, Mora A. Myxedema coma with cardiac tamponade and severe cardiomyopathy. Proc Bayl Univ Med Cent 2015; 28(4): 509-11.
Brent GA, Hershman JM. Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration. J Clin Endocrinol Metab 1986; 63: 1-8.
Pereira VG, Haron ES, Lima-Neto N, Medeiros-Neto G. Management of myxedema coma: Report on three successfully treated patients with nasogastric or intravenous administration of triiodothyronine. J Endocrinol Invest 1982; 5: 331-4.
Hylander B, Rosenqvist U. Treatment of myxedema coma—factors associated with fatal outcome. Acta Endocrinol (Copenh) 1985; 108: 65-71.

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Article Details

Year: 2019
Published on: 29 January, 2019
Page: [13 - 16]
Pages: 4
DOI: 10.2174/1573402114666181001121108
Price: $65

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