In vivo Monitoring of Oxygen Levels in Human Brain Tumor Between Fractionated Radiotherapy Using Oxygen-enhanced MR Imaging

Author(s): Junchao Qian*, Xiang Yu, Bingbing Li, Zhenle Fei, Xiang Huang, Peng Luo, Liwei Zhang, Zhiming Zhang, Jianjun Lou, Hongzhi Wang*

Journal Name: Current Medical Imaging
Formerly: Current Medical Imaging Reviews

Volume 16 , Issue 4 , 2020

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Graphical Abstract:


Abstract:

Background: It was known that the response of tumor cells to radiation is closely related to tissue oxygen level and fractionated radiotherapy allows reoxygenation of hypoxic tumor cells. Non-invasive mapping of tissue oxygen level may hold great importance in clinic.

Objective: The aim of this study is to evaluate the role of oxygen-enhanced MR imaging in the detection of tissue oxygen levels between fractionated radiotherapy.

Methods: A cohort of 10 patients with brain metastasis was recruited. Quantitative oxygen enhanced MR imaging was performed prior to, 30 minutes and 22 hours after first fractionated radiotherapy.

Results: The ΔR1 (the difference of longitudinal relaxivity between 100% oxygen breathing and air breathing) increased in the ipsilateral tumor site and normal tissue by 242% and 152%, respectively, 30 minutes after first fractionated radiation compared to pre-radiation levels. Significant recovery of ΔR1 in the contralateral normal tissue (p < 0.05) was observed 22 hours compared to 30 minutes after radiation levels.

Conclusion: R1-based oxygen-enhanced MR imaging may provide a sensitive endogenous marker for oxygen changes in the brain tissue between fractionated radiotherapy.

Keywords: Oxygen level, brain tumor, oxygen-enhanced magnetic resonance imaging, fractionated radiotherapy, brain metastasis, radiotherapy.

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VOLUME: 16
ISSUE: 4
Year: 2020
Page: [427 - 432]
Pages: 6
DOI: 10.2174/1573405614666180925144814
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