Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using Carboxylic Acids as Catalyst

Author(s): Elham Mir, Ebrahim Mollashahi, Ghasem Marandi*

Journal Name: Current Catalysis

Volume 7 , Issue 3 , 2018

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Graphical Abstract:


Introduction: A one-pot approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in the reaction between 2-aminobezamide and aromatic aldehydes in the presence of highly available carboxylic acids such as benzilic acid, phthalic acid and salicylic acid has been reported.

Material and Methods: Carboxylic acids such as benzilic acid, phthalic acid and salicylic acid, used as efficient catalysts for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones, are structurally stable compounds. Synthesized compounds were characterized by 1H NMR and IR spectroscopy and their melting points are in good agreement with previous reports.

Results: Results show that carboxylic acids such as benzilic acid, phthalic acid and salicylic can act as effective catalysts in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones without any side products in acceptable reaction time.

Conclusion: In conclusion, we use a simple one-pot process for the synthesis of 2,3- dihydroquinazolin-4(1H)-ones by using carboxylic acids which has some advantages such as low cost, nontoxic solvents and simple separation of products.

Keywords: Aromatic aldehydes, 2-aminobenzamide, carboxylic acids, 2, 3-dihydroquinazolin-4(1H)-one derivatives, benzilic acid, salicylic acid.

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Article Details

Year: 2018
Published on: 10 December, 2018
Page: [217 - 223]
Pages: 7
DOI: 10.2174/2211544707666180924125826
Price: $25

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