Differences and Implications of Animal Models for the Study of Alzheimerʼs Disease
Pp. 1-40 (40)
Marcela Bermudez Echeverry, Sonia Guerrero Prieto, Joao Carlos dos Santos Silva, Maria Camila Almeida and Daniel Carneiro Carrettiero
In behavioural neurosciences, animal models are aimed at providing insights
into normal and pathological human behaviour and its underlying neuronal processes.
Alzheimerʼs disease (AD) is the most common origin of dementia in the elderly.
Several factors have been identified, such as the amyloid precursor protein (APP),
hyperphosphorylation of tau protein, and the secretase enzymes. Animal models are
important for elucidation of mechanistic aspects of AD. Transgenic models recapitulate
expression of human β-APP and tau hyperphosphorylation to understand the
pathogenesis of AD. In this chapter, some animal models are reviewed and discussed
briefly in order to elucidate some criteria that an animal model should fulfil to mimic
human neurodegenerative diseases.
Alzheimerʼs disease, Amyloid beta-protein, Animal models, Octodon
degu, Transgenic models.
Center of Mathematics, Computation and Cognition, Federal University of ABC, Sao Bernardo do Campo – SP, Brazil.