Background: Oxazolones and 1,2,3-triazoles are among the extensively studied heterocycles
in medicinal chemistry. Both of these moieties are reported to possess a broad spectrum of biological
activity including antimicrobial.
Objective: The objective of the current work is to design, synthesize and antimicrobial evaluation of
some new oxazolone-1,2,3-triazole hybrids.
Methods: The designed oxazolone-1,2,3-triazole hybrids were synthesized using copper(I)-catalyzed
azide-alkyne cycloaddition. The antimicrobial evaluation was carried out using serial dilution method.
Results: Most of the synthesized hybrids showed significant antimicrobial properties. Some of the
compounds were found to be possessing better or comparable activity to that of the standards used. The
docking simulations results are also in agreement with the antimicrobial activity data.
Conclusion: Sixteen new hybrids were synthesized and tested in vitro for their antimicrobial activity.
Some of the tested compounds exhibited promising antimicrobial activity and could be utilized for the
development of the lead compounds for new and more potent antimicrobial drugs.