Cancer Cell Metabolism Featuring Nrf2

Author(s): Payal Chatterjee*, Mukesh Yadav, Namrata Chauhan, Ying Huang, Yun Luo

Journal Name: Current Drug Discovery Technologies

Volume 17 , Issue 3 , 2020

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Abstract:

Although the major role of Nrf2 has long been established as a transcription factor for providing cellular protection against oxidative stress, multiple pieces of research and reviews now claim exactly the opposite. The dilemma - “to activate or inhibit” the protein requires an immediate answer, which evidently links cellular metabolism to the causes and purpose of cancer. Profusely growing cancerous cells have prolific energy requirements, which can only be fulfilled by modulating cellular metabolism. This review highlights the cause and effect of Nrf2 modulation in cancer that in turn channelize cellular metabolism, thereby fulfilling the energy requirements of cancer cells. The present work also highlights the purpose of genetic mutations in Nrf2, in relation to cellular metabolism in cancer cells, thus pointing out a newer approach where parallel mutations may be the key factor to decide whether to activate or inhibit Nrf2.

Keywords: Nrf2, keap1, Reactive Oxygenation Species [ROS], cancer, oxidative stress, glycolysis, glutathione, Tricarboxylic Acid Cycle [TCA], de novo lipogenesis.

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VOLUME: 17
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Year: 2020
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DOI: 10.2174/1570163815666180911092443
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