Key Signaling Pathways Engaged in Cancer Management: Current Update

Author(s): Sanjiv Singh*, Rahul Shukla

Journal Name: Current Cancer Therapy Reviews

Volume 16 , Issue 1 , 2020

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Graphical Abstract:


Background: Till today cancer is still challenging to treat and needs more active therapeutic approaches. Participation of complex multi-pathway cell propagation instrument is a noteworthy issue in creating active anticancer therapeutic methodologies. Immune evasions, metabolic modifications, imperfect apoptotic component, modification in upstream or downstream RAS signaling, altered nuclear factor kappa B actions, imbalanced autophagy design and distortedly controlled angiogenesis are distinguishing features of cancer.

Methods: On the basis of systemic research and analysis of the current online available database, we analyzed and reported about the key signaling pathway engaged with cancer development outlining the effectiveness of different therapeutic measures and targets that have been created or are being researched to obstruct the cancer development.

Results: A number of signaling pathways, for example, resistant, metabolism, apoptosis, RAS protein, nuclear factor kappa B, autophagy, and angiogenesis have been perceived as targets for drug treatment to control the advancement, development and administration of cancer.

Conclusion: A noteworthy challenge for future medication advancement is to detail a synthesis treatment influencing distinctive targets to enhance the treatment of cancer.

Keywords: Cancer management, key signaling pathways, therapeutic approaches, autophagy, RAS protein, homeostatic controls.

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Year: 2020
Page: [36 - 48]
Pages: 13
DOI: 10.2174/1573394714666180904122412
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