Introduction: This study investigated the in vitro inhibition properties of newly synthesized
coumarin derivates (C1-C5) against human carbonic anhdyrase I (hCA-I) and jack bean urease.
Activities were expressed as IC50 (mg/mL), the concentration reducing 50% of the enzymes. The
IC50 values for hCA-I ranged 5.20 µM from 12.10 µM, with compound C3 exhibiting the highest
activity. The inhibition values for urease ranged 22.30 µM to 39.00 µM, the highest activity being
observed in C5.
Conclusion: Comparing the inhibitions with standard inhibitors of the enzymes, while the samples
exhibited moderate inhibitions against hCA I, high inhibition was determined against urease.
Keywords: Carbonic anhydrase, coumarin, inhibition, jack bean, synthesis compounds, urease.
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