Cardiac Stem Cell Characteristics in Physiological and Pathological Conditions

Author(s): Selçuk Öztürk, Y. Murat Elçin*

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 26 , 2018

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For nearly a century, the adult heart was considered as a post-mitotic organ. The discovery of a resident cardiac stem cell (CSC) population in the heart has dramatically undermined this notion with the support of encouraging preclinical and clinical studies aiming to regenerate the damaged heart after a myocardial infarction (MI). There are two ways to obtain CSCs for transplantation: Allogeneic and autologous sources. Autologous cells may be obtained from the patients’ own tissue. Obtaining cells from diseased patients may contain a risk for altered stem cell characteristics. In addition to MI, these patients may also suffer from pathological conditions such as hypertension, diabetes mellitus, heart failure, congenital heart disease or cancer, which are known to alter CSC characteristics. It is also known that physiological conditions such as aging and death affect CSC functions in the heart. Our knowledge about the CSC characteristics in various physiological and pathological conditions may shed light on our opinion about the regenerative capacity and biological activity of these cells in these situations. Defining these properties may guide the researchers and clinicians in choosing and obtaining the most qualified CSC populations for cardiac regenerative medicine therapies. The purpose of this review is to describe the alterations in CSC characteristics in various physiological and pathological conditions.

Keywords: Cardiac stem cells, regenerative medicine, cell therapy, patient characteristics, cardiovascular disease, myocardial infarction.

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Article Details

Year: 2018
Page: [3101 - 3112]
Pages: 12
DOI: 10.2174/1381612824666180903123817
Price: $65

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PDF: 28
PRC: 1