Synthesis and Medicinal Applications of N-Aryl-C-nitroazoles

Author(s): Sergey S. Chuprun, Grigory Kantin, Mikhail Krasavin*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 20 , 2018

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Graphical Abstract:


The review provides a summary of synthetic approaches to and medicinal applications of N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles implying their inherent toxicity. Therefore, the research literature appears to be lacking in medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area. Therefore, an attempt to summarize, within a single review article, the medicinal applications and methods of synthesis has been undertaken.

Keywords: ANRORC, aromatic nucleophilic substitution, metal-catalyzed, N-arylation, nitroazoles.

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Article Details

Year: 2018
Published on: 12 November, 2018
Page: [1733 - 1752]
Pages: 20
DOI: 10.2174/1389557518666180831101841
Price: $65

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