Title:Synthesis and Medicinal Applications of N-Aryl-C-nitroazoles
VOLUME: 18 ISSUE: 20
Author(s):Sergey S. Chuprun, Grigory Kantin and Mikhail Krasavin*
Affiliation:Saint Petersburg State University, St. Petersburg 199034, Saint Petersburg State University, St. Petersburg 199034, Saint Petersburg State University, St. Petersburg 199034
Keywords:ANRORC, aromatic nucleophilic substitution, metal-catalyzed, N-arylation, nitroazoles.
Abstract:The review provides a summary of synthetic approaches to and medicinal applications of
N-aryl-C-nitroazoles. This broad chemical family delivered numerous practical applications in the areas
other than pharmaceuticals. This is most likely due to a common stigma associated with nitroheterocycles
implying their inherent toxicity. Therefore, the research literature appears to be lacking in
medicinal chemistry reports related to this class of compounds. However, despite this notion, the nitroheterocycles
have enjoyed a marked renaissance in the last years, particularly, in antimicrobial area.
Therefore, an attempt to summarize, within a single review article, the medicinal applications and
methods of synthesis has been undertaken.
