Title:Pleiotropic Effect of Mahanine and Girinimbine Analogs: Anticancer Mechanism and its Therapeutic Versatility
VOLUME: 18 ISSUE: 14
Author(s):V. Lenin Maruthanila, Ramakrishnan Elancheran*, Ajaikumar B. Kunnumakkar, Senthamaraikannan Kabilan and Jibon Kotoky*
Affiliation:Division of Life Sciences, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, Division of Life Sciences, Institute of Advanced Study in Science and Technology, Guwahati-781035, Assam, Department of Biotechnology, Indian Institute of Technology, Guwahati, Assam 781035, Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu 608002, National Institute of Pharmaceutical Education and Research, Guwahati-781032, Assam
Keywords:Mahanine, girinimbine, Murraya species, prevention and therapy, apoptosis, pleiotropic anticancer.
Abstract:Emerging evidence present credible support in favour of the potential role of mahanine and girinimbine.
Non-toxic herbal carbazole alkaloids occur in the edible part of Murraya koenigii, Micromelum minutum,
M. zeylanicum, and M. euchrestiolia. Mahanine and girinimbine are the major potent compounds from these species.
In fact, they interfered with tumour expansion and metastasis development through down-regulation of apoptotic and
antiapoptotic protein, also involved in the stimulation of cell cycle arrest. Consequently, these compounds were well
proven for the in-vitro and in vivo evaluation that could be developed as novel agents either alone or as an adjuvant
to conventional therapeutics. Therefore, mahanine and girinimbine analogs have the potential to be the promising
chemopreventive agents for the tumour recurrence and the treatment of human malignancies. In this review, an
updated wide-range of pleiotropic anticancer and biological effects induction by mahanine and girinimbine against
cancer cells were deeply summarized.
