Potential Prognostic, Diagnostic and Therapeutic Markers for In-stent Reocclusion in Advanced Age Patients After Coronary Stenting

Author(s): Xia Li*, Fenglin Zhang, Hualan Zhou, Youdong Hu, Xiang Fang, Dianxuan Guo, Ying Chen

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 28 , 2018

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Background: Oxidative stress and inflammatory response played important roles in advanced atherosclerosis. We tried to confirm clinical diagnostic significance of the assessments of oxidative stress and inflammatory response status with in-stent reocclusion in 283 advanced age patients (80~90 years) after coronary stenting.

Methods: We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), acrolein(ACR), and paraoxonase-1 (PON-1)in advanced age patients with in-stent restenosis and reocclusion after coronary stenting.

Results: Levels of SOD3, eNOS, NO and PON-1 were lowered (P<0.001) and levels of MDA and ACR were increased (P<0.001).

Conclusion: The assessments of the biomarkers of oxidative stress and inflammatory response (levels of MDA and ACR) and anti-oxidant biomarkers (levels of eNOS, NO, SOD3 and PON-1) could be considered as potential prognostic and diagnostic indicators of in-stent reocclusion in advanced age patients after coronary stenting.

Keywords: Coronary heart disease, coronary stenting, coronary artery, in-stent reocclusion, atherosclerosis, oxidative stress.

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Article Details

Year: 2018
Published on: 07 December, 2018
Page: [3359 - 3365]
Pages: 7
DOI: 10.2174/1381612824666180830141918
Price: $65

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