Recent Finding in Repair of the Peripheral Nerve Lesions Using Pharmacological Agents: Common Methods for Evaluating the Repair Process

Author(s): Dheyauldeen Shabeeb, Masoud Najafi, Mansor Keshavarz, Ahmed Eleojo Musa, Gholamreza Hassanzadeh, Mohammed Reza Hadian, Alireza Shirazi*

Journal Name: Central Nervous System Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Central Nervous System Agents

Volume 18 , Issue 3 , 2018

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Graphical Abstract:


Introduction: Peripheral nerve lesion is a common clinical problem that may produce longterm functional defects. Usually, crush injuries, fractures, scars, lacerations, compression, or iatrogenic reasons are reasons for nerve injuries. Unsuccessful treatment of nerve injuries causes partial or total loss of sense, motor, and autonomic functions. Despite widespread experimental studies that aimed to improve nerve healing, healing results for peripheral nerve injuries are hardly reasonable. The successes of the regenerative procedure of the nerve repair in experimental research, with topical agents, can be assessed using different methods such as morphological, electrophysiological, biochemical and functional evaluation. Although, most researchers confirm that despite good microsurgical repair and topical application of these substances, complete regeneration and functional recovery of the injured nerves are almost never achieved.

Conclusion: This study aimed to make a comparison between topical pharmacological agents at the peripheral nerve lesion and methods used for evaluating the success of the repair process. For this purpose, we reviewed studies conducted on some of the most commonly used pharmacological agents as well as their properties in the repair of peripheral nerve lesions.

Keywords: Biochemical, electrophysiological, functional evaluation, histo-morphological, peripheral nerve injury, peripheral nerve, pharmaceutical agents.

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Article Details

Year: 2018
Published on: 29 August, 2018
Page: [161 - 172]
Pages: 12
DOI: 10.2174/1871524918666180830101953
Price: $65

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