Effects of Bioactive Peptide on Inflammatory Bowel Disease, Focus on Signal Transduction and Intestinal Microbiota

Author(s): Yong Ma, Wenxin Yan, Sujuan Ding, Yanquan Fei, Gang Liu*, Jun Fang*

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 24 , 2018

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Inflammatory Bowel Diseases (IBD) are now widely receiving attention. There are many reasons why people get IBD; for example, environment, smoking, family heredity, intestinal microbiota and so on. Antibiotics have not been proven effective and those suffering from IBD have begun to look for other effective drugs to treat the chronic disease. Bioactive peptides are a good candidate among alternative drugs tested so far, and have been seen to control bodily growth, development, immune regulation and metabolism. This paper will review the literature describing the effects of bioactive peptides on intestinal inflammation. Studies conducted using in vivo models and clinical trials provide evidence that bioactive peptides can be effective in mitigating intestinal inflammation.

Keywords: Inflammatory bowel diseases, bioactive peptide, intestinal microbiota, defensins, chronic disease, antibiotics.

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Article Details

Year: 2018
Published on: 08 November, 2018
Page: [2782 - 2788]
Pages: 7
DOI: 10.2174/1381612824666180829103945
Price: $65

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