Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy

Author(s): Xiaolin Deng, Yangmei Xie, Yinghui Chen*

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 17 , Issue 10 , 2018

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Graphical Abstract:


Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways.

Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.

Keywords: Refractory epilepsy, ABC transporter, P-glycoprotein, breast cancer resistance protein, multidrug resistanceassociated protein, neuroinflammation, NF-κB, drug resistance.

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Article Details

Year: 2018
Page: [728 - 735]
Pages: 8
DOI: 10.2174/1871527317666180828121820
Price: $65

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PDF: 56