This review depicts in a concise way the oxidation reactions (C-H, double bond
and oxidative cleavage) in natural products. The introduction of oxygen atom in natural
products is an improved strategy to achieve pharmacologically active molecules or their
synthetic analogues. Natural products are considered most intriguing skeletons to be synthesized
in the laboratory mainly because they are blessed with multifunctional groups in
one entity. The presence of more than one functional group in the molecules provokes the
daunting tasks such as functional group tolerance and regio- or chemo-selectivity.
Oxidation reaction is one of the widely exercised reactions in natural products chemistry
as it renders the formation of new derivatives or analogues just by insertion of oxygen
atom. Over the past decades, several oxidants have been reported but among all, the oxidant
dimethyldioxirane (DMDO) holds great promise as it is attributed with mild reactivity, high functional
group tolerance, excellent chemo- and regio-selectivity, ecofriendly and is easy to use and prepare, so these
fascinating features provide immense incentive to natural product chemist to insert oxygen atom with great
ease in natural products.
Keywords: Natural products, DMDO, oxygen atom introduction, oxidation, dimethyldioxirane, oxidant.
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