Models of Parkinson’s Disease with Special Emphasis on Drosophila melanogaster

Author(s): Ambreen Fatima, Smita Jyoti, Yasir Hasan Siddique*

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 17 , Issue 10 , 2018

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Graphical Abstract:


Background & Objective: Parkinson’s disease is the second most common neurodegenerative disorder affecting more than 1% of the population averaged 60 years of age. The majority of PD cases are sporadic and are probably caused by a combination of risk factors but 5-10% of the PD cases are familial. Due to the high degree of the gene, conservation in humans, mice and insects using an animal model system is a valuable approach to further elucidate the roles of the genes in PD.

Conclusion: The present review highlights the models used to study PD symptoms with special emphasis on Drosophila.

Keywords: Parkinson's disease, models, Drosophila, pathological, neurdegerative disorder, etiology.

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Article Details

Year: 2018
Published on: 23 November, 2018
Page: [757 - 766]
Pages: 10
DOI: 10.2174/1871527317666180820164250
Price: $65

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