Title:Sarcosine as a Novel and Recyclable Organocatalyst: A Greener Approach Towards the Synthesis of Multisubstituted Pyrazole Derivatives
VOLUME: 5 ISSUE: 3
Author(s):Deepali Jaiswal, Jyoti Tiwari, Shailesh Singh, Amit Kumar Sharma, Jaya Singh and Jagdamba Singh*
Affiliation:Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, Department of Chemistry, LRPG College, Sahibabad, Ghaziabad-201005, Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002
Keywords:Catalysis, glycerol, green synthesis, pyrazole, sarcosine.
Abstract:Background: A highly efficient eco-friendly route for the synthesis of pyrazole derivatives
from readily available chalcones/1, 3-diketones and hydrazines in glycerol using sarcosine as a novel
organopromoter has been developed. To the best of our knowledge this is the first report on the use of
sarcosine as an organocatalyst in organic transformations.
Results and Methods: This method manifests several attributes of green chemistry like atomeconomy,
reusability of catalyst, short reaction time and an eco-friendly medium.
Conclusion: The present protocol can serve as a valuable green alternative to the existing methods for
the synthesis of targeted molecules.
