Breast Cancer Stem Cells and Sex Steroid Hormones

Iván       Flores-Ramírez; Noemi       Baranda-Avila; Elizabeth       Langley
Abstract

Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes breast cancer stem cell origin, signaling pathways involved in self-renewal, such as Wnt, Notch and Hedgehog, biomarkers linked to stemness, and the role of sex steroid hormones in BCSC regulation.
Keywords: Breast cancer, breast cancer stem cells, biomarkers, signaling pathways, estrogen receptor, progesterone receptor.
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DOI https://dx.doi.org/10.2174/1574888X13666180810121415	Print ISSN 1574-888X
Publisher Name Bentham Science Publisher	Online ISSN 2212-3946
Current Stem Cell Research & Therapy

Breast Cancer Stem Cells and Sex Steroid Hormones

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