Mesenchymal stem cells (MSCs) are pluripotent stem cells isolated from adipose tissue
(AD-MSCs), bone marrow (BM-MSCs) and umbilical cord (UC-MSCs). Due to their ability to
differentiate into multiple cell types, homing to injury sites and immunosuppressive properties have
been proposed as a promising option in regenerative medicine. Studies have shown that the majority
of regenerative effects of MSCs are exerted through their paracrine effects. Moreover, it has been
shown that some of the regenerative functions of MSCs are mediated by exosomes, and MSC-derived
exosomes play a vital role in the treatment of diseases. Since angiogenesis is a crucial process in the
regeneration of damaged tissues, this review discusses the angiogenic capabilities of MSC-derived
exosomes (MSC-DEs) and their mechanisms that are responsible for the control of angiogenesis in
wound healing, cardiovascular diseases (CVDs) and bone defects.
Keywords: Angiogenesis, cardiovascular diseases, exosome, mesenchymal stem cell, regenerative medicine, wound healing.
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