Title:Engineered Silver Nanoparticles, A New Nanoweapon Against Cancer
VOLUME: 18 ISSUE: 14
Author(s):Mohammad A. Ebrahimzadeh, Alireza Tafazoli, Javad Akhtari, Pourya Biparva and Shahram Eslami*
Affiliation:Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Department of Endocrinology, Diabetology and Internal Medicine, Clinical Research Center, Medical University of Bialystok, 15-276 Bialystok, Immunogenetics Research Center, Department of Physiology and Pharmacology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Department of Basic Sciences, Sari University of Agricultural Sciences and Natural Resources, Sari, Pharmaceutical Sciences Research Center, Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari
Keywords:Silver nanoparticles, green synthesis, antioxidant, cancer, p53, apoptasis.
Abstract:New modifications in nanoparticles changed their applications obviously. Green synthesis of
nanoparticles and their biomedical utilizations have been the focus of increasing attention in recent years. Silver
nanoparticles (AgNPs) demonstrated surprising effects and many advantageous features for cancer therapy.
Investigations indicated the anticancer activity of AgNPs in different ways, comprising cell cycle arrest, DNA
damaging and apoptosis, alteration of P53 function, up/down regulation of some important cytokine genes and
so on. But some key inquiries like the ability to control the accidental effects of AgNPs, or encompassing process
for parcels, which reduces the toxicological profile of nanoparticles, still remained. “Green synthesis” of
nanoparticles has been shown to be a kind of approach to resolve the toxicity amounts in a range of 10-18 times.
Using distinctive properties of this approach, i.e. as green synthesized silver nanoparticles (G-AgNPs), in order
to raise potential therapeutic efficacy, even up to two-fold higher than cis-platin, is going to play a crucial role in
cancer treatment and could be considered as a new insight in this field. The current review focuses on the antioxidant
activity of G-AgNPs and potential impacts on cancer cells.
