Synthetic Strategies, Chemical Reactivities and Biological Activities of 3-Thioxo-1,2,4-Triazin-5-Ones and Their Derivatives

Author(s): Mohammad S.T. Makki, Reda M. Abdel-Rahman, Abdulrahman S. Alharbi*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 16 , Issue 4 , 2019

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Graphical Abstract:


In recent years, a very interest in the synthesis of functionalized 3-thioxo-1,2,4-triazin-5- ones and their derivatives as vital probes has been increased, due to the important, applications of the medicinal, pharmacological, and biological field as a drug, semi drug, and bioactive systems. The present work review outlines extensive recent advances literature survey on the synthesis of sulfurbearing 1,2,4-triazin-5-one derivatives has been reconsidered. Also, the behavior of these family towards electrophilic and nucleophilic reagents in different media and conditions reported. The biological evaluation of the most synthesized systems included anticancer, anti-HIV, antimicrobial as well as their enzymatic effects (cellobiase produced by fungi) have been reported. The reactivity of these systems depends on the polarity of solvent, temperature, molarity as well as a type of tautomeric present.

Keywords: 3-Thioxo-1, 2, 4-triazin-5-one, anti-HIV, biocidal effects, cytotoxicity, α-ketoesters, Sulfur compounds, thioxotriazinone.

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Article Details

Year: 2019
Published on: 19 March, 2019
Page: [308 - 322]
Pages: 15
DOI: 10.2174/1570193X15666180807124325
Price: $65

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