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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Letter Article

2-Acryloyl-4,5-methylenedioxyphenol: A Small Molecule Endowed with Antidermatophytic Activity

Author(s): Marco Zuccolo, Sabrina Dallavalle*, Raffaella Cincinelli, Luce Mattio, Stefania Mazzini, Michelandrea De Cesare and Loana Musso

Volume 16, Issue 4, 2019

Page: [461 - 466] Pages: 6

DOI: 10.2174/1570180815666180803115347

Price: $65

Abstract

Background: Superficial fungal infections are the most common fungal diseases in humans, affecting more than 25% of the population worldwide.

Methods: In the present study, we have investigated the activity of kakuol, a natural compound isolated from the rhizomes of Asarum sieboldii, and some analogues, against various dermatophytes and pharmacologically relevant yeasts.

Results: One of the tested compounds, 2-acryloyl-4,5-methylenedioxyphenol, showed a broadspectrum activity against most of the fungal species assayed, resulting particularly effective against dermatophyte strains (MIC values in the range of 0.25-0.5 µg/mL, two/four-fold lower than the positive control miconazole).

Conclusion: The results suggest that this molecule can be considered a promising starting point for the development of new antifungal compounds.

Keywords: Kakuol, Asarum sieboldii, antifungal agents, Candida albicans, dermatophytes, 3, 4-methylenedioxyphenol.

Graphical Abstract
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