Background: Prostatitis is a recurrent urinary infection in males and is often difficult to
cure. The aim of the study was to examine whether anti-inflammatory effects of enhanced drainage
of prostatic secretions, obtained through two months treatment with a proteolytic enzyme mucoactive
(PEM) compound (Serrazyme and other constituents), influenced qualitative or quantitative
expressions of bacterial growth in seminal cultures.
Method: 450 patients with prostatitis syndromes were randomized either to PEM therapy (intervention
group) or to no treatment group. All patients were followed at the end of a 2-month PEM
continuous treatment period (T2) and further two months after withdrawal (T4).
Results: After treatment, 15 out of 107 (14.1%) patients with Chronic Bacterial Prostatitis (CBP)
showed negative seminal cultures, while in patients with cat NIH-IIIA prostatitis seminal cultures
became positive in 33.3% cases with low bacteriospermia.
After two months from withdrawal, although among CBP patients the total number of isolates and
colony forming units (CFU) counts showed not significant changes compared to matched-values
observed at T2, microbial parameters varied significantly among inflammatory prostatitis patients.
Conclusion: The results of the present study showed that 2 months of treatment with PEM,
decreasing bacterial adherence and inflammatory prostatitis, reveals a subgroup of apparent
inflammation associated with infection that microbial biofilms likely mask in inflammatory