Background: Skin cancers are the most common malignancy in humans, and the number of
cases has increased dramatically in the past few decades. Therefore, it is very important to carry out
studies concerning new and safer anticancer natural agents (e.g. perillyl alcohol) and modern drug delivery
systems, such as nanoformulations, which increase their bioavailability.
Objectives: The aim of this work was to obtain different kinds of topical vehicles formulation and compare
their efficiency in the release of perillyl alcohol. The release kinetics was determined by using
certain selected mathematical models.
Method: Formulations of a hydrogel, O/W nanoemulsion, O/W macroemulsion and nanostructured
lipid carrier were developed as carriers for perillyl alcohol – one of the promising anticancer natural
agents. The release study of the active agents was carried out using the Spectra/Por Standard Regenerated
Cellulose membrane, at temperature T=320C. The concentration of active agents in the receptor
solution was analyzed by high performance liquid chromatography. The release kinetics was determined
by using selected mathematical models.
Results: The results of our release studies have shown that the highest and comparable amount of
perillyl alcohol was released from hydrogel (35.72 ± 0.21%), NLC (35.54 ± 1.48%) and nanoemulsion
(34.87 ± 4.49%). The release was found to follow Fickian diffusion in the case of hydrogel and macroemulsion,
while an anomalous mechanism was observed in the case of nanoformulations. Nevertheless,
the obtained nanoformulations, as well as a conventional hydrogel, may be considered potential
vehicles in topical delivery of perillyl alcohol.