Title:The Dopaminergic Dysfunction and Altered Working Memory Performance of Aging Mice Lacking Gamma-synuclein Gene
VOLUME: 17 ISSUE: 8
Author(s):Viktor S. Kokhan, Tat`yana G. Kokhan, Anna N. Samsonova, Vladimir P. Fisenko, Aleksey A. Ustyugov and Gjumrakch Aliev*
Affiliation:Institute of Biomedical Problems RAS, Moscow, Specialized Multidisciplinary Hospital №1 of Ukrainian Ministry of Health, Dnipro, Institute of Physiologically Active Compounds RAS, Chernogolovka, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Str., 8, bld. 2, Moscow, 119991, Institute of Physiologically Active Compounds RAS, Chernogolovka, Institute of Physiologically Active Compounds RAS, Chernogolovka
Keywords:Gamma-synuclein, working memory, passive-avoidance test, and amphetamine induced locomotion, soluble proteins,
neural tissue.
Abstract:Background: It was previously shown that inactivation of gamma-synuclein which is a
small soluble neuronal protein affects psycho-emotional status and cognitive abilities in knock-out
mice.
Objective: Determine the role of gamma-synuclein inactivation on memory performance in aging animals.
Method: We used the passive avoidance test and acute amphetamine administration in aging gammasynuclein
knock-out mice.
Results: As a result, we found moderate aging-unlinked deficit of dopaminergic neurotransmitter system
of gamma-synuclein knock-out mice. At the same time, the evidence of progressive synaptic vesicle
trafficking machinery impairment was obtained.
Conclusion: Therefore most likely these dysfunctions are associated with a reduction in the highefficient
learning performance in tests that require intact working memory.
