Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism

Author(s): Nurul ‘Ain Arshad, Teoh Seong Lin, Mohamad Fairuz Yahaya*

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 17 , Issue 8 , 2018

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Graphical Abstract:


Background & Objective: Metabolic syndrome (MetS) is an interconnected group of physiological, biochemical, clinical and metabolic factors that directly increase the risk of cardiovascular disease, type 2 diabetes mellitus (T2DM) and mortality. Rising evidence suggests that MetS plays a significant role in the progression of Alzheimer’s disease and other neurodegenerative diseases. Nonetheless, the factors linking this association has not yet been elucidated. As we are facing an increasing incidence of obesity and T2DM in all stages of life, understanding the association of MetS and neurodegenerative diseases is crucial to lessen the burden of the disease.

Conclusion: In this review, we will discuss the possible mechanisms which may relate the association between MetS and cognitive decline which include vascular damages, elevation of reactive oxygen species (ROS), insulin resistance and low-grade inflammation.

Keywords: Metabolic syndrome, brain effect, possible pathology, insulin resistance, International Diabetic Federation (IDF), diagnosis.

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Article Details

Year: 2018
Published on: 24 July, 2018
Page: [595 - 603]
Pages: 9
DOI: 10.2174/1871527317666180724143258
Price: $65

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