N-Halo Reagents-Mediated Greener Protocols for Heterocyclic Synthesis: Safe Chemistry and Pot-Economy Approaches to Azoles and Quinoxalines

Title:N-Halo Reagents-Mediated Greener Protocols for Heterocyclic Synthesis: Safe Chemistry and Pot-Economy Approaches to Azoles and Quinoxalines

Volume: 5 Issue: 2

Author(s): Vitor S. C. de Andrade and Marcio C. S. de Mattos*

Affiliation:

• Departamento de Quimica Organica, Instituto de Quimica, Universidade Federal do Rio de Janeiro, Rio de Janeiro,Brazil

Keywords: Thiazoles, oxazoles, isoxazoles, imidazoles, quinoxalines, heterocycles, synthesis.

Abstract: Quinoxaline and azole heterocyclic compounds (thiazoles, imidazoles, oxazoles, etc.) are important compounds from both an academic and industrial points of view. Furthermore, they have a great interest in medicinal chemistry due to their biological and pharmacological activities. The development of environmentally friendly synthetic methodologies that allow access to quinoxaline and azole nucleus is of critical interest to the scientific community. Recently, the research into new reagents that can accomplish a safe and efficient heterocyclic synthesis has grown enormously. The present review summarizes the utilization of N-halo compounds (e.g N-halosuccinimides, trihaloisocyanuric acids, N-halosulfonamides, etc.) as safe reagents for the construction of quinoxalines, thiazoles, oxazoles, imidazoles and related compounds.

Cite this article as:

de Andrade S. C. Vitor and de Mattos C. S. Marcio*, N-Halo Reagents-Mediated Greener Protocols for Heterocyclic Synthesis: Safe Chemistry and Pot-Economy Approaches to Azoles and Quinoxalines, Current Green Chemistry 2018; 5 (2) . https://dx.doi.org/10.2174/2452273202666180719124023