Abstract
Neurodegenerative diseases are likely to emerge as the second cause of mortality in the world in coming years. NDDs cause tremendous financial burden on the healthcare system along with profound effect on families and patient. Disease-modifying treatment strategies with proven efficacy for these disorders are still lacking. Documentation proved that oxidative stress plays a leading role in the pathophysiology of many neurodegenerative disorders. Molecules with good antioxidant profile could be explored for the doctoring of these conditions. Neuroprotective effects of bioflavonoid morin have been well recognized in the literature. Morin being super antioxidant compound helped in preventing and curing these disorders by suppression of ROS and by inhibition of multiple targets. In this review, we tried to explain various neuropathological conditions with their target sites and neurobiological mechanisms of morin.
Keywords: Morin, Neurodegenerative disease, Herbal, Polyphenolic compound, Flavonoid, Alzheimer`s disease.
Current Topics in Medicinal Chemistry
Title:Role of Morin in Neurodegenerative Diseases: A Review
Volume: 18 Issue: 11
Author(s): Ritu Kataria, Eduardo Sobarzo-Sanchez*Anurag Khatkar*
Affiliation:
- Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Campus Vida, 15782 Santiago de Compostela,Spain
- Faculty of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana 124001,India
Keywords: Morin, Neurodegenerative disease, Herbal, Polyphenolic compound, Flavonoid, Alzheimer`s disease.
Abstract: Neurodegenerative diseases are likely to emerge as the second cause of mortality in the world in coming years. NDDs cause tremendous financial burden on the healthcare system along with profound effect on families and patient. Disease-modifying treatment strategies with proven efficacy for these disorders are still lacking. Documentation proved that oxidative stress plays a leading role in the pathophysiology of many neurodegenerative disorders. Molecules with good antioxidant profile could be explored for the doctoring of these conditions. Neuroprotective effects of bioflavonoid morin have been well recognized in the literature. Morin being super antioxidant compound helped in preventing and curing these disorders by suppression of ROS and by inhibition of multiple targets. In this review, we tried to explain various neuropathological conditions with their target sites and neurobiological mechanisms of morin.
Export Options
About this article
Cite this article as:
Kataria Ritu, Sobarzo-Sanchez Eduardo*, Khatkar Anurag*, Role of Morin in Neurodegenerative Diseases: A Review, Current Topics in Medicinal Chemistry 2018; 18 (11) . https://dx.doi.org/10.2174/1568026618666180711153416
DOI https://dx.doi.org/10.2174/1568026618666180711153416 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Towards A Multimodal Treatment of Depression: A Minireview on the Potential Role of Antibiotics
Mini-Reviews in Medicinal Chemistry Patenting Activities Related to Biomedical Applications of Fullerenes
Recent Patents on Nanomedicine Insights on the Neuromodulatory Propensity of Selaginella (Sanjeevani) and its Potential Pharmacological Applications
CNS & Neurological Disorders - Drug Targets Potential Drugs and Methods for Preventing or Delaying the Progression of Huntington's Disease
Recent Patents on CNS Drug Discovery (Discontinued) Polyglutamine and Neurodegeneration: Structural Aspects
Protein & Peptide Letters Coping with Stress During Aging: The Importance of a Resilient Brain
Current Neuropharmacology Self-Assembling Peptide Nanofibrous Scaffolds for Tissue Engineering: Novel Approaches and Strategies for Effective Functional Regeneration
Current Protein & Peptide Science Induced Pluripotent Stem Cells (iPSCs) Derived from Different Cell Sources and their Potential for Regenerative and Personalized Medicine
Current Molecular Medicine Neurogenesis and Stroke
CNS & Neurological Disorders - Drug Targets A Friend in Need May Not be a Friend Indeed: Role of Microglia in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Sirtuins as Possible Targets in Neurodegenerative Diseases
Current Drug Targets Properties and Pathogenicity of Prion-Derived Peptides
Protein & Peptide Letters Preface
Current Medicinal Chemistry Treatment Possibilities for Psychosis in Parkinson's Disease with An Emphasis on the Newly Approved Drug: Pimavanserin
CNS & Neurological Disorders - Drug Targets Structural and Molecular Basis of Carbohydrate-Protein Interaction Systems as Potential Therapeutic Targets
Current Pharmaceutical Design Therapeutic Approaches to the Challenge of Neuronal Ceroid Lipofuscinoses
Current Pharmaceutical Biotechnology The Blood Brain Barrier and its Role in Alzheimer's Therapy: An Overview
Current Drug Targets Calpain-1 and Calpain-2 in the Brain: Dr. Jekill and Mr Hyde?
Current Neuropharmacology Blood-based Amyloid and Tau Biomarker Tests For Alzheimer’s Disease
Neuroscience and Biomedical Engineering (Discontinued) Mitochondrial Calcium Signaling as a Therapeutic Target for Alzheimer’s Disease
Current Alzheimer Research