Title:Iodine Catalyzed Highly Efficient One Pot Three Component Synthesis of 4-arylidene-3-methylisoxazol-5 (4H) -one in Aqueous Medium
VOLUME: 5 ISSUE: 2
Author(s):Srinivas L. Nakkalwar, Shivaji B. Patwari, Mohasim M. Patel and Vivekanand B. Jadhav*
Affiliation:Department of Chemistry, Lal Bahadur Shastri College, Dharmabad, Dist.-Nanded, (MH), Pin-431 809, Department of Chemistry, Lal Bahadur Shastri College, Dharmabad, Dist.-Nanded, (MH), Pin-431 809, Department of Chemistry, Shri Muktanand College, Gangapur, Dist.-Aurangabad, (MH), Pin-431 109, Department of Chemistry, Shri Muktanand College, Gangapur, Dist.-Aurangabad, (MH), Pin-431 109
Keywords:Aromatic aldehydes containing an electron donating groups, hydroxylamine hydrochloride, ethyl acetoacetate, 4-
arylidene-3-methylisoxazol-5(4H)-ones, iodine & water.
Abstract:An efficient one-pot three-component reaction of ethyl acetoacetate with hydroxylamine
hydrochloride and various aromatic aldehydes containing an electron donating group, was carried out.
The current protocol gives diverse 4-arylidene-3-methylisoxazol-5 (4H) -ones providing good to excellent
yield of products in an aqueous medium using iodine as a catalyst. This particular cyclocondensation
reaction was performed in water, which is an environmentally benign universal solvent
having unique properties being clean, efficient, inexpensive, and readily available.
