Adiantum capillus-veneris L. is one of the best ferns that are used in traditional
medicine for breaking kidney stones. This study aimed to evaluate antioxidant activity of
the different extracts of A. capillus-veneris using the phosphomolybdenum assay, free
radical scavenging activity (DPPH), ferric reducing antioxidant power (FRAP), and cupric
ion reducing power activity test (CUPRAC). Besides, the enzyme inhibition activities
were determined against acetylcholinesterase, tyrosinase, α-glucosidase and α-amylase.
Total and individual phenolic compounds were also determined by spectrophotometric
and HPLC methods, respectively. Total phenolic and flavonoid contents were found to
change between 354-441 mg GAE/g and 23-123 mg QE/g, respectively. The major phenolic
compounds were benzoic acid, epicatechin, syringic acid and catechin. Methanol and
ethyl acetate extracts exhibited stronger antioxidant abilities compared to water extract. A. capillus-veneris extracts
showed high enzyme inhibition activities except for butrylcholinesterase. The results indicated that the
different extracts of A. capillus-veneris L. can be used as natural sources of antioxidants and enzyme inhibitors.