Synthesis of 3-Arylindazole-1-acetic Acids and In Vitro Study of Potential Antibacterial Effect

Author(s): Fauzia Anjum Chattha, Samina Kousar, Mehr-un-Nisa, Munawar Ali Munawar*

Journal Name: Letters in Drug Design & Discovery

Volume 16 , Issue 4 , 2019

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Graphical Abstract:


Background: Indazoleacetic acids and their pharmaceutically acceptable salts have been claimed to be useful as anti-inflammatory, analgesic and antipyretic agents. They are active in the treatment of respiratory diseases such as asthma, bronchitis, allergies and obstructive pulmonary diseases.

Objectives: We report herein a feasible study concerned about the design, synthesis, structure and in vitro antimicrobial activity of 3-arylindazole-1-acetic acids derivatives. Series of compounds were synthesized by alkylation of 3-arylindazoles.

Method: Synthesized compounds were subjected to study the effect on microbial growth in vitro. All synthesized compounds were found to exhibit antibacterial activities against a range of grampositive (Bacillus subtilis, Staphylococcus aureus) and gram-negative bacteria (Shigella sonnei, Escherichia coli) by broth dilution method.

Results: The synthesized compounds exhibited antibacterial activities comparable to fluoroquinolones and some compounds exhibited better activity. These findings suggest a great potential of 3-arylindazole-1-acetic acids as antibacterial compounds.

Conclusion: 3-Arylindazole-1-acetic acids are potent antimicrobial agent better than their respective 3-arylindazoles that revealed moderate activity against both gram positive and gram negative bacteria.

Keywords: 3-aryl-indazoles-1-acetic acids, inhibition, fluoroquinolones, gram positive, gram negative, indazoles.

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Article Details

Year: 2019
Published on: 08 March, 2019
Page: [401 - 407]
Pages: 7
DOI: 10.2174/1570180815666180702152259
Price: $65

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